Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial
نویسندگان
چکیده
The probabilistic reward task (PRT) has identified learning impairments in those with major depressive disorder (MDD), as well anhedonia-specific impairments. However, attempts to validate the have produced inconsistent findings. Thus, we seek determine whether Reward Behavior Disengagement (RBD), our proposed economic augmentation of PRT, differs between MDD participants and controls, there is a level at which RBD high enough for depressed be considered objectively disengaged. Data were gathered part Establishing Moderators Biosignatures Antidepressant Response Clinical Care (EMBARC) study, double-blind, placebo-controlled clinical trial antidepressant response. Participants included 195 individuals moderate severe (Quick Inventory Depressive Symptomatology (QIDS–SR) score ≥ 15), not treatment depression, complete PRT data. Healthy controls (n = 40) had no history psychiatric illness, QIDS–SR < 8, treated sertraline or placebo 8 weeks (stage I EMBARC trial). was applied data using discriminant analysis, classified engaged 137) disengaged 58), relative controls. engaged/disengaged groups compared on sociodemographic features, reward–behavior, sertraline/placebo response (Hamilton Depression Rating Scale scores). responded only sertraline, whereas who (F(1293) 4.33, p 0.038). did differ otherwise. predictive impairment patients may utility identifying will benefit from antidepressants.
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ژورنال
عنوان ژورنال: Behavioral sciences
سال: 2023
ISSN: ['2076-328X']
DOI: https://doi.org/10.3390/bs13080619